El documental analiza las tiras de prensa humorísticas de los USA, entrevistando a: Jean Schulz, viuda de Charles M. Schulz (Peanuts, 1950–2000); Mort Walker (Beetle Bailey, 1950–); Jeff Keane (The Family Circus, 1960–); Cathy Guisewite (Cathy, 1976–2010); Jim Davis (Garfield, 1978–); Bill Watterson (Calvin and Hobbes, 1985–1995); Greg Evans (Luann, 1985–); Bill Amend (FoxTrot, 1988–); Jerry Holkins (Penny Arcade, 1998–); Mike Krahulik (Penny Arcade, 1998–); Jeph Jacques (Questionable Content, 2003–); Richard Thompson (Cul de Sac, 2004–2012); Karl Kerschl (The Abominable Charles Christopher, 2007–); Kate Beaton (Hark! A Vagrant, 2008–); Matthew Inman (The Oatmeal, 2009–)